Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 43, Issue 7, Pages 2058-2068Publisher
WILEY
DOI: 10.1002/hed.26668
Keywords
carcinoma; fluorodeoxyglucose F18 positron‐ emission tomography; neoplasms; second primary; squamous cell; unknown primary
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Funding
- GE Healthcare
- Alfred and Annemarie von Sick for translational and clinical cardiac
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This retrospective study on head and neck carcinoma patients found that FDG-PET-CT/MRI led to significant changes in pretherapeutic N classification, with a 18.7% cumulative incidence of distant metastases and second primaries detected.
Background To assess the effect of 18-fluorodeoxyglucose positron emission tomography (FDG-PET) in the pretherapeutic staging of N classification, detection rate of distant metastases, and second primaries. Methods Retrospective study on patients with head and neck carcinoma. We compared pretherapeutic N classification by ultrasound, computed tomography (CT)/magnetic resonance imaging (MRI), and FDG-PET-CT/MRI. Results A change in the N classification due to FDG-PET-CT/MRI was observed in 116 patients (39.5%) compared to N classification by ultrasound and fine-needle aspiration cytology. Patients with advanced nodal classification (>N2a) were more likely to be reclassified. Distant metastases were detected in 19 patients and a total of 36 second primaries were diagnosed by FDG-PET-CT/MRI. Detection of distant metastases was more likely in regional advanced disease (>N2a). Smokers (>10 py) had a significantly higher risk of second primary. Conclusion FDG-PET-CT/MRI leads to a significant change in pretherapeutic N classification. The cumulative incidence of distant metastases and second primaries was 18.7%.
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