4.7 Article

Intramyocardial stem cell injection: go(ne) with the flow

Journal

EUROPEAN HEART JOURNAL
Volume 38, Issue 3, Pages 184-186

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehw056

Keywords

Stem cell therapy; Intracardiac injections; Venous drainage

Funding

  1. Dutch Ministry of Economic Affairs, Agriculture and Innovation
  2. Alexandre Suerman program for MD/PhD students of the University Medical Center Utrecht, the Netherlands
  3. ZonMw-TAS program [116002016]
  4. Netherlands CardioVascular Research Initiative (CVON): the Dutch Heart Foundation
  5. Dutch Federation of University Medical Centers
  6. Netherlands Organization for Health Research and Development
  7. Royal Netherlands Academy of Sciences
  8. Dutch Heart Foundation

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In this study, we visualize the real-time dynamics of intramyocardial stem-cell injections. This shows a massive, immediate wash-out via venous drainage, accounting for the low retention. The use of carriers reduces this outflow.

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