Microphthalmia-Associated Transcription Factor in Senescence and Age-Related Diseases

Although microphthalmia-associated transcription factor (MITF) has been known for decades as a key regulator for melanocytic differentiation, recent studies expanded its other roles in multiple biological processes. Among these newfound roles, the relationship between MITF and aging is attractive; however, the underlying mechanism remains elusive. Here, we review the documented cues that highlight the implication of MITF in the aging process and particularly discuss the possible mechanisms underlying the participation of MITF in cellular senescence. First, it summarizes the association of MITF with melanocytic senescence, including the roles of MITF in cell cycle regulation, DNA damage repair, oxidative stress response, and the generation of senescence-associated secretory phenotype. Then, it collects the information involving MITF-related senescent changes in nonmelanocytes, such as retinal pigment epithelium cells, osteoclasts, and cardiomyocytes. This review may deepen the understanding of MITF function and be helpful to develop new strategies for improving geriatric health.

Automated summary

MITF, known as a key regulator for melanocytic differentiation, has been found to play other roles in various biological processes, including its involvement in aging. This review summarizes the potential mechanisms underlying MITF's participation in cellular senescence, highlighting its roles in cell cycle regulation, DNA damage repair, oxidative stress response, and the generation of senescence-associated secretory phenotype.