Dynamic plantar pressure patterns in children and adolescents with Charcot-Marie-Tooth disease

Background: The dynamic plantar pressure patterns of children and adolescents with Charcot-Marie-Tooth (CMT) disease and its relationship to musculoskeletal alterations may help to understand the natural history of the disease and improve therapeutic interventions. Research question: The study compared dynamic plantar pressure patterns in children and adolescents with and without CMT. It also tested the associations between isometric muscle strength (IMS), passive range of motion (ROM), foot posture and dynamic plantar pressure patterns in CMT. Methods: This cross-sectional study compared children and adolescents (aged 8?18 years) with CMT (n = 40) with a typical group (n = 40). The plantar pressure distribution during gait was recorded, and the contact area (CA), peak pressure (PP), contact time (CT) and pressure-time integral (PTI) in five foot regions (rearfoot, midfoot lateral, midfoot medial, lateral forefoot and medial forefoot) were analysed. The IMS of the dorsiflexors and plantar flexors, passive ROM, and foot posture were also recorded. Results: PP (medial midfoot and medial forefoot) and PTI (rearfoot, lateral midfoot and medial forefoot) were higher in children with CMT compared with the typical group. The adolescents with CMT presented a less CA (whole foot) and a higher CT (medial midfoot) when compared with typical group. For CMT, in the medial midfoot, plantar flexor IMS associated with PP (13=-11.54, p = 0.01) and PTI (13=-3.38, p = 0.04); supinated foot posture associated with PP (13 = 33.89, p = 0.03) and PTI (13 = 12.01, p = 0.03). Significance: Children with CMT showed clear changes in most of the dynamic plantar pressure variables, while adolescents with CMT showed changes mostly in CA and CT. This information together with the associations established between supinated foot, dorsiflexion ROM and plantar flexions IMS can be useful for guiding rehabilitation professionals in their therapies.

Automated summary

This study compared the dynamic plantar pressure patterns in children and adolescents with and without CMT, finding clear changes in most dynamic plantar pressure variables for children with CMT and changes mainly in contact area and contact time for adolescents with CMT. Associations were found between supinated foot posture, dorsiflexion ROM, and plantar flexion IMS in CMT patients, which can be useful for guiding rehabilitation therapies.