Journal
FUTURE ONCOLOGY
Volume 17, Issue 25, Pages 3343-3353Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2021-0266
Keywords
colorectal cancer; CORRELATE; metastatic; multikinase inhibitor; regorafenib
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Funding
- Bayer
- Roche
- Merck Serono
- Merck
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The real-world evidence from the French cohort of the CORRELATE study demonstrates that regorafenib is a safe and effective treatment option for metastatic colorectal cancer, aligning with findings from Phase III clinical trials and the global CORRELATE population.
Aim: We report real-world evidence with regorafenib in previously treated metastatic colorectal cancer from the French cohort of the international, prospective, observational CORRELATE study. Patients & methods: Patients receiving regorafenib according to French health authority approval were included. The primary end point was treatment-emergent adverse events. Overall survival and progression-free survival were secondary end points. Results: Two hundred and forty-two patients (61% male, median age: 66 years) were enrolled. The most common grade >= 3 drug-related treatment-emergent adverse events were hand-foot skin reaction (10.3%), asthenia/fatigue (9.9/1.2%) and hypertension (6.2%). Median overall survival and progression-free survival were 6.8 (95% CI: 6.3-7.6) and 2.8 months (95% CI: 2.6-3.0), respectively. Conclusion: The real-world safety and effectiveness data of regorafenib in metastatic colorectal cancer in France align with findings from Phase III clinical trials and the global CORRELATE population.
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