Journal
FUTURE MICROBIOLOGY
Volume 16, Issue 5, Pages 323-340Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2020-0145
Keywords
arthropod; entomology; MALDI-TOF MS; mosquitos; ticks; vector
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Funding
- A*MIDEX project - Investissements d'Avenir French Government programme [ANR-11-IDEX-0001-02]
- Delegation Generale pour l'Armement (DGA, MoSIS project) [PDH-2-NRBC-2-B-2113]
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This study summarizes the latest advances in the use of matrix-assisted laser desorption ionization time-of-flight mass spectrometry in the identification of arthropod vectors, including expanded identification range, applications in detecting blood feeding behavior, and identifying infection status.
Arthropod vectors have historically been identified morphologically, and more recently using molecular biology methods. However, both of these methods are time-consuming and require specific expertise and equipment. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry, which has revolutionized the routine identification of microorganisms in clinical microbiology laboratories, was recently successfully applied to the identification of arthropod vectors. Since then, the robustness of this identification technique has been confirmed, extended to a large panel of arthropod vectors, and assessed for detecting blood feeding behavior and identifying the infection status in regard to certain pathogenic agents. In this study, we summarize the state-of-the-art of matrix-assisted laser desorption ionization time-of-flight mass spectrometry applied to the identification of arthropod vectors (ticks, mosquitoes, phlebotomine sand-flies, fleas, triatomines, lice and Culicoides), their trophic preferences and their ability to discriminate between infection statuses.
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