Journal
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
Volume 266, Issue 8, Pages 765-769Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00406-016-0693-6
Keywords
BDNF; BDNF pro-peptide; Depression; Learned helplessness; proBDNF; Stress resilience
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Strategic Research Program for Brain Sciences, AMED, Japan
- China Scholarship Council
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Using learned helplessness (LH) model of depression, we measured protein expression of brain-derived neurotrophic factor (BDNF) pro-peptide, BDNF precursors (proBDNF and preproBDNF) in the brain regions of LH (susceptible) and non-LH rats (resilience). Expression of preproBDNF, proBDNF and BDNF pro-peptide in the medial prefrontal cortex of LH rats, but not non-LH rats, was significantly higher than control rats, although expression of these proteins in the nucleus accumbens of LH rats was significantly lower than control rats. This study suggests that regional differences in conversion of BDNF precursors into BDNF and BDNF pro-peptide by proteolytic cleavage may contribute to stress resilience.
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