Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 167, Issue -, Pages 232-242Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2021.03.010
Keywords
CoQ; Cyt c; Supercomplexes; Respirasomes; Pools
Funding
- MINECO [SAF2015-65633-R, RTI2018-099357-B-I00]
- HFSP [RGP0016/2018]
- CIBER [CB16/10/00282]
- Instituto de Salud Carlos III (ISCIII)
- Ministerio de Ciencia, Innovacion y Universidades (MCNU)
- Pro CNIC Foundation
- Severo Ochoa Center of Excellence [SEV-2015-0505]
- Spanish Government grant (ISCIII agency)
- Spanish Government grant (AEI agency)
- European Union FEDER/ERDF
Ask authors/readers for more resources
Electron transfer between respiratory complexes is crucial for mitochondrial oxidative phosphorylation efficiency, involving a coordinated interplay between complexes and supercomplexes in the inner mitochondrial membrane to meet a spectrum of metabolic needs.
Electron transfer between respiratory complexes is an essential step for the efficiency of the mitochondrial oxidative phosphorylation. Until recently, it was stablished that ubiquinone and cytochrome c formed homogenous single pools in the inner mitochondrial membrane which were not influenced by the presence of respiratory supercomplexes. However, this idea was challenged by the fact that bottlenecks in electron transfer appeared after disruption of supercomplexes into their individual complexes. The postulation of the plasticity model embraced all these observations and concluded that complexes and supercomplexes co-exist and are dedicated to a spectrum of metabolic requirements. Here, we review the involvement of superassembly in complex I stability, the role of supercomplexes in ROS production and the segmentation of the CoQ and cyt c pools, together with their involvement in signaling and disease. Taking apparently conflicting literature we have built up a comprehensive model for the segmentation of CoQ and cyt c mediated by supercomplexes, discuss the current limitations and provide a prospect of the current knowledge in the field.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available