4.7 Article

Does membrane curvature elastic energy play a role in mediating oxidative stress in lipid membranes?

Journal

FREE RADICAL BIOLOGY AND MEDICINE
Volume 171, Issue -, Pages 191-202

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2021.05.021

Keywords

Oxidative stress; Intrinsic curvature hypothesis; Lipid oxidation; Membrane curvature; Curvature elastic energy; Curvature elastic stress

Ask authors/readers for more resources

Oxidative stress affects lipid membranes by reducing stored curvature elastic energy, which can potentially be mitigated by compounds that increase stored curvature elastic energy; Age-related changes in lipid composition may represent a homeostatic response of cells to compensate for the accumulation of in vivo lipid oxidation products.
The effects of oxidative stress on cells are associated with a wide range of pathologies. Oxidative stress is predominantly initiated by the action of reactive oxygen species and/or lipoxygenases on polyunsaturated fatty acid containing lipids. The downstream products are oxidised phospholipids, bioactive aldehydes and a range of Schiff base by-products between aldehydes and lipids, or other biomacromolecules. In this review we assess the impact of oxidative stress on lipid membranes, focusing on the changes that occur to the curvature preference (lipid spontaneous curvature) and elastic properties of membranes, since these biophysical properties modulate phospholipid homeostasis. Studies show that the lipid products of oxidative stress reduce stored curvature elastic energy in membranes. Based upon this observation, we hypothesize that the effects of oxidative stress on lipid membranes will be reduced by compounds that increase stored curvature elastic energy. We find a strong correlation appears across literature studies that we have reviewed, such that many compounds like vitamin E, Curcumin, Coenzyme Q10 and vitamin A show behaviour consistent with this hypothesis. Finally, we consider whether age-related changes in lipid composition represent the homeostatic response of cells to compensate for the accumulation of in vivo lipid oxidation products.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available