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Role of Hydrogen Peroxide in NF-κB Activation: From Inducer to Modulator
Virginia Oliveira-Marques et al.
ANTIOXIDANTS & REDOX SIGNALING (2009)
Characterization of Dasatinib and Its Structural Analogs as CYP3A4 Mechanism-Based Inactivators and the Proposed Bioactivation Pathways
Xiaohai Li et al.
DRUG METABOLISM AND DISPOSITION (2009)
Inflammation in Atherosclerosis From Pathophysiology to Practice
Peter Libby et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)
Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence
Olga Moiseeva et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
David E. Harrison et al.
NATURE (2009)
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Francis Rodier et al.
NATURE CELL BIOLOGY (2009)
Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity
Tobias B. Dansen et al.
NATURE CHEMICAL BIOLOGY (2009)
A crucial role for adipose tissue p53 in the regulation of insulin resistance
Tohru Minamino et al.
NATURE MEDICINE (2009)
Reactive oxygen intermediate-induced pathomechanisms contribute to immunosenescence, chronic inflammation and autoimmunity
Thorsten Peters et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2009)
Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
Arturo V. Orjalo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans
Jeremy M. Van Raamsdonk et al.
PLOS GENETICS (2009)
STATs in cancer inflammation and immunity: a leading role for STAT3
Hua Yu et al.
NATURE REVIEWS CANCER (2009)
NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
Guang-Hui Liu et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2008)
ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
Christin Tse et al.
CANCER RESEARCH (2008)
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
Thomas Kuilman et al.
CELL (2008)
Metformin slows down aging and extends life span of female SHR mice
Vladimir N. Anisimov et al.
CELL CYCLE (2008)
Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin
Andreas Kampkoetter et al.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2008)
ROS and p53: A versatile partnership
Bin Liu et al.
FREE RADICAL BIOLOGY AND MEDICINE (2008)
Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
Ryan Doonan et al.
GENES & DEVELOPMENT (2008)
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
William G. Kaelin et al.
MOLECULAR CELL (2008)
AMPK phosphorylation of raptor mediates a metabolic checkpoint
Dana M. Gwinn et al.
MOLECULAR CELL (2008)
Puzzles, promises and a cure for ageing
Jan Vijg et al.
NATURE (2008)
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Jean-Philippe Coppe et al.
PLOS BIOLOGY (2008)
A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcino genic properties
M. Harwood et al.
FOOD AND CHEMICAL TOXICOLOGY (2007)
Selective oxidative stress in cell nuclei by nuclear-targeted D-amino acid oxidase
Patrick J. Halvey et al.
ANTIOXIDANTS & REDOX SIGNALING (2007)
Butyrate mediates decrease of histone acetylation centered on transcription start sites and down-regulation of associated genes
Alvaro Rada-Iglesias et al.
GENOME RESEARCH (2007)
Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts
S. J. Ryu et al.
CELL DEATH AND DIFFERENTIATION (2007)
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
Joao F. Passos et al.
PLOS BIOLOGY (2007)
Cellular senescence: when bad things happen to good cells
Judith Campisi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Cellular senescence in aging primates
U Herbig et al.
SCIENCE (2006)
Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex
DD Sarbassov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Oxidative stress augments the production of matrix metalloproteinase-1, cyclooxygenase-2, and prostaglandin E2 through enhancement of NF-κB activity in lipopolysaccharide-activated human primary monocytes
YB Lu et al.
JOURNAL OF IMMUNOLOGY (2005)
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
T Oltersdorf et al.
NATURE (2005)
Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity
M De Martinis et al.
FEBS LETTERS (2005)
Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas
H Duan et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Understanding the odd science of aging
TBL Kirkwood
CELL (2005)
BTB protein keap1 targets antioxidant transcription factor nrf2 for ubiquitination by the cullin 3-Roc1 ligase
M Furukawa et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
A dynamic role of HAUSP in the p53-Mdm2 pathway
MY Li et al.
MOLECULAR CELL (2004)
The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress
T Nguyen et al.
FREE RADICAL BIOLOGY AND MEDICINE (2004)
Bcl-2 is a key factor for cardiac fibroblast resistance to programmed cell death
M Mayorga et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
JG Wood et al.
NATURE (2004)
Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b
D Ciais et al.
ONCOGENE (2004)
Proteasome inhibition induces a senescence-like phenotype in primary human fibroblasts cultures
N Chondrogianni et al.
BIOGERONTOLOGY (2004)
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a
U Herbig et al.
MOLECULAR CELL (2004)
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
H Van Remmen et al.
PHYSIOLOGICAL GENOMICS (2003)
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
KT Howitz et al.
NATURE (2003)
Reversal of human cellular senescence:: roles of the p53 and p16 pathways
CM Beauséjour et al.
EMBO JOURNAL (2003)
Central role of the proteasome in senescence and survival of human fibroblasts - Induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation
N Chondrogianni et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
M Narita et al.
CELL (2003)
Curcurnin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
E Balogun et al.
BIOCHEMICAL JOURNAL (2003)
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
A Krtolica et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53
A Seluanov et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Subcytotoxic H2O2 stress triggers a release of transforming growth factor-β1, which induces biomarkers of cellular senescence of human diploid fibroblasts
C Frippiat et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)