Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 150, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2021.112063
Keywords
Lead; Lead-induced neurotoxicity; Calcium; Inflammation; Autophagy; Apoptosis
Categories
Funding
- National Natural Science Foundation of China [NSFC 81773476]
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Lead, a heavy metal pollutant, has a significant impact on the nervous system, causing neurotoxicity and various neurological disorders. Studies have shown that lead can affect cellular pathways, calcium homeostasis, apoptosis, inflammation, and other mechanisms leading to nervous system injury.
Lead is a heavy metal pollutant that is widely present in the environment. It affects every organ system, yet the nervous system appears to be the most sensitive and primary target. Although many countries have made significant strides in controlling Pb pollution, Pb poisoning continuous to be a major public health concern. Exposure to Pb causes neurotoxicity that ranges from neurodevelopmental disorders to severe neurodegenerative lesions, leading to impairments in learning, memory, and cognitive function. Studies on the mechanisms of Pb-induced nervous system injury have convincingly shown that this metal can affect a plethora of cellular pathways affecting on cell survival, altering calcium dyshomeostasis, and inducing apoptosis, inflammation, energy metabolism disorders, oxidative stress, autophagy and glial stress. This review summarizes recent knowledge on multiple signaling pathways associated with Pb-induced neurological disorders in vivo and in vitro.
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