Journal
FITOTERAPIA
Volume 150, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2021.104846
Keywords
Entandrophragma angolense; Meliaceae; Limonoid; Triterpenoid; seco-triterpenoid; Cytotoxicity; Quantitative NMR
Categories
Funding
- National Cancer Institute, U.S.A. [P01 CA125066]
Ask authors/readers for more resources
Four new compounds (1-4) were isolated from the stem bark of Entandrophragma angolense along with eleven known structures (5-15). Compound 5 showed moderate cytotoxicity against MDA-MB-231, OVCAR3, MDA-MB-435, and HT29 cell lines, with IC50 values ranging from 2.0-5.9 μM.
Four new compounds (1-4) were isolated from the stem bark of Entandrophragma angolense along with eleven known structures (5-15). The chemical structures were elucidated on the basis of spectroscopic and HRMS data, and the absolute configuration was established with the aid of electronic circular dichroism. Compound 5 displayed moderate cytotoxicity against MDA-MB-231, OVCAR3, MDA-MB-435, and HT29 cell lines, with IC50 values ranging from 2.0-5.9 mu M.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
