Journal
FITOTERAPIA
Volume 152, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2021.104937
Keywords
Phenylspirodrimane; Marine-derived fungus; Stachybotrys sp; Antibacterial activity
Categories
Funding
- Finance Science and Technology Project of Hainan Province [ZDKJ202018]
- K.C.Wong Education Foundation [GJTD-2020-12]
- Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]
- Special Support Program for Training High-Level Talents in Guangdong [2019TQ05H299]
- Project of Xinjiang Production AMP
- Construction Corps Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin [BRZD1805, BRZD1806]
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Five new phenylspirodrimanes were isolated from a marine-derived fungus, along with four known compounds. Their structures were determined through spectroscopic analyses, and two of the compounds exhibited moderate antibacterial activities against various bacteria.
Five new phenylspirodrimanes, stachybomycins A & iexcl; E (1-5), together with four known compounds (6-9), were isolated from the marine-derived fungus Stachybotrys sp. SCSIO 40434. Their structures were elucidated by comprehensive spectroscopic analyses of NMR and HRESIMS. The absolute configuration of 1 was confirmed by single crystal X-ray diffraction analysis. Compounds 5 and 7 showed moderate antibacterial activities against Micrococcus luteus, Staphylococcus aureus and methicillin resistant Staphylococcus aureus with minimal inhibition concentration (MIC) values of 8, 16 and 16 mu g mL-1, respectively.
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