Journal
FEBS LETTERS
Volume 595, Issue 13, Pages 1819-1824Publisher
WILEY
DOI: 10.1002/1873-3468.14104
Keywords
COVID-19; IgA; TGF-beta 1; SARS-CoV-2
Funding
- Key Projects of Shenzhen Science and Technology Plan [JSGG20200225153031960]
- Shenzhen Science and Technology Project [KQTD20170331145453160]
- Shenzhen Nanshan District Pioneer Group Research Funds [LHTD20180007]
- National Natural Science Foundation of China [81803202]
- COVID-19 Prevention and Control from the China Postdoctoral Science Foundation [2020T130024ZX]
- Zhejiang University special scientific research funding [2020XGZX001, 2020XGZX025]
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The study found that serum levels of TGF-beta 1 significantly increased in the early and middle stages of COVID-19 and were correlated with the levels of SARS-CoV-2-specific IgA and the APACHE II score in patients with severe disease. The findings suggest TGF-beta 1 may play a key role in COVID-19, based on the genetic association of the TGF-beta 1 activator THBS3 with severe COVID-19 identified by the COVID-19 Host Genetics Initiative.
We previously observed enhanced immunoglobulin A (IgA) responses in severe COVID-19, which might confer damaging effects. Given the important role of IgA in immune and inflammatory responses, the aim of this study was to investigate the dynamic response of the IgA isotype switch factor TGF-beta 1 in COVID-19 patients. We observed, in a total of 153 COVID-19 patients, that the serum levels of TGF-beta 1 were increased significantly at the early and middle stages of COVID-19, and correlated with the levels of SARS-CoV-2-specific IgA, as well as with the APACHE II score in patients with severe disease. In view of the genetic association of the TGF-beta 1 activator THBS3 with severe COVID-19 identified by the COVID-19 Host Genetics Initiative, this study suggests TGF-beta 1 may play a key role in COVID-19.
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