4.6 Review

Neutrophils in cancer, a love-hate affair

Journal

FEBS JOURNAL
Volume 289, Issue 13, Pages 3692-3703

Publisher

WILEY
DOI: 10.1111/febs.16022

Keywords

granulopoiesis; immunomodulation; neutrophil heterogeneity; prometastatic neutrophils; tumour stroma; Tumour-associated neutrophils

Funding

  1. Transatlantic network of excellence form the Leducq Foundation [TNE-18CVD04]
  2. CRI Irvington postdoctoral fellowship [CRI3511]
  3. MICINN
  4. Pro-CNIC Foundation

Ask authors/readers for more resources

The article discusses the important role of neutrophils in various solid tumors, exploring their functional diversity, tumor specificity, and research on therapeutic enhancement.
Neutrophils dominate the immunological landscape of multiple types of solid tumours in mice and humans and exert different pro- or antitumoral activity. This functional heterogeneity has prompted a search for different subsets and classifications of tumour-infiltrating neutrophils with the idea of better delineating their specific roles in cancer. In this review, we describe current studies that highlight specific mechanisms by which neutrophils exert pro- or antitumoral function and focus on how distinct tumour types induce unique functional states in neutrophils, co-opt granulopoiesis, modulate neutrophil ageing and prolong the neutrophil life span. In addition, we discuss how the tissue-specific tumour stroma and the stage of the cancer influence the function and number of tumour-infiltrating neutrophils. Finally, we explore different approaches to enhance the therapeutic efficacy in cancer types dominated by neutrophils.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available