4.6 Article

Cysteine 159 delineates a hinge region of the alternating access monocarboxylate transporter 1 and is targeted by cysteine-modifying inhibitors

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

SLC16 Family: From Atomic Structure to Human Disease

Patrick D. Bosshart et al.

Summary: The SLC16 family consists of diverse membrane proteins mediating the transport of monocarboxylates across biological membranes, playing roles in nutrient transport, intracellular pH regulation, and thyroid hormone homeostasis. Alterations in expression levels and transport function of specific SLC16 transporters are associated with severe health disorders, while members transporting L-lactate play crucial roles in tumor metabolism. Structural information from a SLC16 homolog sheds new light on the family, discussing their role in cancer metabolism and potential for anticancer therapy through their inhibition.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

Article Biochemistry & Molecular Biology

Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates

Nan Wang et al.

Summary: The study presents cryo-EM structures of human MCT1 bound to lactate or inhibitors, shedding light on its substrate binding and transport mechanism, as well as providing a framework for structure-guided drug discovery targeting MCTs.
Article Multidisciplinary Sciences

Basigin drives intracellular accumulation of l-lactate by harvesting protons and substrate anions

Anna-Lena Koepnick et al.

Summary: Transmembrane transport by members of the MCT family is crucial in human physiology and cancer development. The interaction with accessory protein basigin enhances intracellular accumulation of l-lactate. The study suggests that the Ig-I domain of basigin plays a key role in driving lactate uptake by increasing proton and substrate concentration at the MCT entry site.

PLOS ONE (2021)

Article Biochemistry & Molecular Biology

Extracellular lysine 38 plays a crucial role in pH-dependent transport via human monocarboxylate transporter 1

Atsushi Yamaguchi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2020)

Article Multidisciplinary Sciences

Cooperative transport mechanism of human monocarboxylate transporter 2

Bo Zhang et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Mechanistic basis of L-lactate transport in the SLC16 solute carrier family

Patrick D. Bosshart et al.

NATURE COMMUNICATIONS (2019)

Article Chemistry, Analytical

6,7-dimethoxy-coumarin as a probe of hydration dynamics in biologically relevant systems

Avisek Ghose et al.

METHODS AND APPLICATIONS IN FLUORESCENCE (2018)

Article Biochemistry & Molecular Biology

Lactate Metabolism in Human Lung Tumors

Brandon Faubert et al.

Article Multidisciplinary Sciences

Identity of a Plasmodium lactate/H+ symporter structurally unrelated to human transporters

Binghua Wu et al.

NATURE COMMUNICATIONS (2015)

Review Biochemistry & Molecular Biology

The SLC16 gene family - Structure, role and regulation in health and disease

Andrew P. Halestrap

MOLECULAR ASPECTS OF MEDICINE (2013)

Article Biochemistry & Molecular Biology

The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein

Matthew J. Ovens et al.

BIOCHEMICAL JOURNAL (2010)

Review Pharmacology & Pharmacy

The SLC16 monocaboxylate transporter family

D. Meredith et al.

XENOBIOTICA (2008)

Article Biochemistry & Molecular Biology

AtGAT1, a high affinity transporter for γ-aminobutyric acid in Arabidopsis thaliana

A Meyer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

The Protein Data Bank

HM Berman et al.

NUCLEIC ACIDS RESEARCH (2000)