Journal
FEBS JOURNAL
Volume 289, Issue 10, Pages 2723-2735Publisher
WILEY
DOI: 10.1111/febs.15860
Keywords
atopic dermatitis; cytokines; dorsal root ganglia; integrin receptors; itch; keratinocytes; mast cells; periostin; TRP channels; TSLP
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Funding
- NIAMS [AR077692-01]
- Zoetis LLC
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Understanding the mechanisms of itch in cutaneous allergic diseases is crucial for developing new therapeutic approaches to relieve itch. Recent studies have focused on endogenous mediators released from immune/nonimmune skin cells and the receptors on sensory neurons, offering potential for more effective treatment of allergic itch.
Millions of people globally suffer from allergic diseases, and the cases have been rising in the past decades. One of the major manifestations of allergic diseases is itch, which is an unpleasant symptom that triggers the urge to scratch and greatly affects the quality of life. Thus, research on how sensation of itch is detected/transmitted from the contact of the allergen to the nervous system is crucial in mitigating itch. Recent studies have attempted to elucidate the mechanisms of itch in allergic diseases. Here, we aim to review the endogenous mediators released from immune/nonimmune skin cells (that are indirectly involved in the propagation of itch) and the sensory neurons that express receptors for these itch mediators that are associated with direct transmission of itch in cutaneous allergic diseases. As the mechanisms for allergic itch become clearer, new therapeutic approaches to relieve itch are likely to be developed. Recent clinical trials are testing numerous compounds that target the endogenous mediators and their receptors. These studies provide the possibility of more effective itch treatment for allergic diseases.
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