DESIGN, SYNTHESIS, CHARACTERIZATION, AND CYTOTOXICITY EVALUATION OF NEW 4-BENZYL-1,3-OXAZOLE DERIVATIVES BEARING 4-(4-CHLOROPHENYLSULFONYL)PHENYL MOIETY

This paper presents the design, synthesis, characterization, and cytotoxicity evaluation of eight organic compounds that have in their molecules the 4-(4-chlorophenylsulfonyl)phenyl moiety: four acyclic precursors derived from phenylalanine (one N-acyl-alpha-amino acid, one N-acyl-alpha-amino acyl chloride, and two N-acyl-alpha-amino ketones), and four cyclization products: one 1,3-oxazol-5(4H)-one, and three 1,3-oxazoles substituted in 5-position with phenyl, p-tolyl, and m-xylyl group, respectively. Structures of synthesized compounds were confirmed by elemental analysis and spectral methods (UV-Vis, FT-IR, MS, H-1 and C-13-NMR). The compounds purity determination was performed by RP-HPLC. Cytotoxic effect of synthesized compounds was evaluated on Daphnia magna crustacean.

Automated summary

This study presents the design, synthesis, characterization, and cytotoxicity evaluation of eight organic compounds containing the 4-(4-chlorophenylsulfonyl)phenyl moiety. The structures of synthesized compounds were confirmed by elemental analysis and spectral methods, and their purity was determined by RP-HPLC. The cytotoxic effect of the synthesized compounds was evaluated on Daphnia magna crustacean.