Journal
FARMACIA
Volume 69, Issue 2, Pages 299-306Publisher
SOC STIINTE FARMACEUTICE ROMANIA
DOI: 10.31925/farmacia.2021.2.15
Keywords
imidazole; hemiaminal; antibacterial activity; surfactants
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The study shows that 2-methyl-1-hydroxymethylimidazole (HIM) exhibits moderate inhibitory and bactericidal activity, especially against Staphylococcus strains. The interaction between HIM and surfactants is limited.
The purpose of paper was to study the antibacterial activity of 2-methyl-1-hydroxymethylimidazole, the hemiaminal of 2-methylimidazole (HIM) by using macrodilution broth method and time-kill assay. Average inhibitory activity of HIM was moderate and its ability to kill bacteria was variable, and displayed a concentration-dependent pattern. Most evident inhibitory activity of HIM was found for the two Staphylococcus strains which were killed in less than 2 h of exposure at 16 MIC while the response of Gram-negative strains was more variable as time-kill dynamics, depending on the bacterial species. Interaction of HIM with some surface active agents has been also evaluated and it was found that synergistic or antagonic effects were very limited between HIM, on the one hand, and SDS and polysorbate 80 (Tween 80), on the other.
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