4.2 Article

Carbohydrate metabolism in trypanosomatids: New insights revealing novel complexity, diversity and species-unique features

Related references

Note: Only part of the references are listed.
Review Parasitology

Evolving Differentiation in African Trypanosomes

Juan F. Quintana et al.

Summary: Parasite differentiation is essential for adaptation to hosts and environments, with the transition between vertebrate and insect stages being well studied in African trypanosomes. Activation of advantageous metabolic pathways in the insect host leads to the formation of a 'stumpy' form. Various stimuli and stress conditions can trigger similar changes, suggesting a repurposing of a generic stress response for gains in parasite fitness during transmission.

TRENDS IN PARASITOLOGY (2021)

Article Multidisciplinary Sciences

Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice

Iain W. McNae et al.

Summary: The parasitic protist Trypanosoma brucei relies on glycolysis for ATP production and has challenging drug targets due to the highly conserved active sites of glycolytic enzymes. Novel allosteric inhibitors of trypanosome phosphofructokinase have been developed to block glycolysis, showing rapid parasite kill times in a murine model of Human African Trypanosomiasis. The study demonstrates the possibility of targeting glycolysis with species-specific inhibitors to tackle various proliferative or infectious diseases.

NATURE COMMUNICATIONS (2021)

Article Infectious Diseases

Nucleotide sugar biosynthesis occurs in the glycosomes of procyclic and bloodstream form Trypanosoma brucei

Maria Lucia Sampaio Guther et al.

Summary: In Trypanosoma brucei, all nucleotide sugar biosynthesis is compartmentalized to the glycosomes in both lifecycle stages, unlike other eukaryotes. The study identifies the specific enzymatic biotransformations involved in this process and notes the heterogeneity of glycosome contents.

PLOS NEGLECTED TROPICAL DISEASES (2021)

Review Parasitology

A Leap Into the Unknown - Early Events in African Trypanosome Tranmission

Balazs Szoor et al.

TRENDS IN PARASITOLOGY (2020)

Article Biochemistry & Molecular Biology

Effect of lysine acetylation on the regulation of Trypanosoma brucei glycosomal aldolase activity

Ariely Barbosa Leite et al.

BIOCHEMICAL JOURNAL (2020)

Review Immunology

Structure, Properties, and Function of Glycosomes in Trypanosoma cruzi

Wilfredo Quinones et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Review Immunology

The Influence of Environmental Cues on the Development of Trypanosoma cruzi in Triatominae Vector

Raissa de Fatima Pimentel Melo et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Article Biochemistry & Molecular Biology

ATP regulates the activity of an alternative oxidase in Trypanosoma brucei

Luis Alberto Luevano-Martinez et al.

FEBS LETTERS (2020)

Article Multidisciplinary Sciences

Landscapes of Protein Posttranslational Modifications of African Trypanosoma Parasites

Naiwen Zhang et al.

ISCIENCE (2020)

Article Infectious Diseases

Genome-scale metabolic models highlight stage-specific differences in essential metabolic pathways in Trypanosoma cruzi

Isabel S. Shiratsubaki et al.

PLOS NEGLECTED TROPICAL DISEASES (2020)

Article Biochemistry & Molecular Biology

The ASCT/SCS cycle fuels mitochondrial ATP and acetate production in Trypanosoma brucei

Kota Mochizuki et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2020)

Article Biochemistry & Molecular Biology

Proteomic analysis of glycosomes from Trypanosoma cruzi epimastigotes

Hector Acosta et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2019)

Article Biochemistry & Molecular Biology

The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction

Peter M. Fernandes et al.

BIOCHEMICAL JOURNAL (2019)

Review Microbiology

Quorum sensing in African trypanosomes

Federico Rojas et al.

CURRENT OPINION IN MICROBIOLOGY (2019)

Article Biochemical Research Methods

Comparative Proteomic Analysis of Lysine Acetylation in Trypanosomes

Nilmar Silvio Moretti et al.

JOURNAL OF PROTEOME RESEARCH (2018)

Article Biochemistry & Molecular Biology

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor

Meng Yuan et al.

BIOCHEMICAL JOURNAL (2018)

Review Cell Biology

AMPK: Sensing Glucose as well as Cellular Energy Status

Sheng-Cai Lin et al.

CELL METABOLISM (2018)

Article Biochemistry & Molecular Biology

Leishmania mexicana can utilize amino acids as major carbon sources in macrophages but not in animal models

Eleanor C. Saunders et al.

MOLECULAR MICROBIOLOGY (2018)

Article Biochemistry & Molecular Biology

Inorganic polyphosphate interacts with nucleolar and glycosomal proteins in trypanosomatids

Raquel S. Negreiros et al.

MOLECULAR MICROBIOLOGY (2018)

Article Microbiology

Gluconeogenesis is essential for trypanosome development in the tsetse fly vector

Marion Wargnies et al.

PLOS PATHOGENS (2018)

Article Biology

African trypanosomes and brain infection - the unsolved question

Stefan Mogk et al.

BIOLOGICAL REVIEWS (2017)

Article Biochemistry & Molecular Biology

Glycosomes: A comprehensive view of their metabolic roles in T-brucei

Stefan Allmann et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Metabolomic profiling reveals a finely tuned, starvation-induced metabolic switch in Trypanosoma cruzi epimastigotes

Maria Julia Barison et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Biochemistry & Molecular Biology

NADH dehydrogenase of Trypanosoma brucei is important for efficient acetate production in bloodstream forms

Sachin V. Surve et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2017)

Article Multidisciplinary Sciences

Targeting pathogen metabolism without collateral damage to the host

Jurgen R. Haanstra et al.

SCIENTIFIC REPORTS (2017)

Review Biochemistry & Molecular Biology

Biogenesis, maintenance and dynamics of glycosomes in trypanosomatid parasites

Jurgen R. Haanstra et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Article Microbiology

Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice

Sandra Trindade et al.

CELL HOST & MICROBE (2016)

Article Biochemistry & Molecular Biology

Targeting glycolysis in the malaria parasite Plasmodium falciparum

David D. van Niekerk et al.

FEBS JOURNAL (2016)

Article Biochemistry & Molecular Biology

The origin and evolution of the acidocalcisome and its interactions with other organelles

Roberto Docampo

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2016)

Article Biochemistry & Molecular Biology

Peroxisomes in parasitic protists

Toni Gabaldon et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2016)

Article Parasitology

Trypanosoma cruzi contains two galactokinases; molecular and biochemical characterization

Angel E. Lobo-Rojas et al.

PARASITOLOGY INTERNATIONAL (2016)

Review Parasitology

The Pentose Phosphate Pathway in Parasitic Trypanosomatids

Julie Kovarova et al.

TRENDS IN PARASITOLOGY (2016)

Article Cell Biology

Molecular control of irreversible bistability during trypanosome developmental commitment

Maria Rosa Domingo-Sananes et al.

JOURNAL OF CELL BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Combining reverse genetics and nuclear magnetic resonance-based metabolomics unravels trypanosome-specific metabolic pathways

Frederic Bringaud et al.

MOLECULAR MICROBIOLOGY (2015)

Article Biochemistry & Molecular Biology

Glycosomal Targets for Anti-Trypanosomatid Drug Discovery

X. Barros-Alvarez et al.

CURRENT MEDICINAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Contribution of Pyruvate Phosphate Dikinase in the Maintenance of the Glycosomal ATP/ADP Balance in the Trypanosoma brucei Procyclic Form

Kamel Deramchia et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemical Research Methods

High-Confidence Glycosome Proteome for Procyclic Form Trypanosoma brucei by Epitope-Tag Organelle Enrichment and SILAC Proteomics

Maria Lucia S. Guether et al.

JOURNAL OF PROTEOME RESEARCH (2014)

Review Biochemistry & Molecular Biology

In or out? On the tightness of glycosomal compartmentalization of metabolites and enzymes in Trypanosoma brucei

Jurgen R. Haanstra et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2014)

Article Biochemistry & Molecular Biology

Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase

Emmanuel Oluwadare Balogun et al.

MOLECULAR MICROBIOLOGY (2014)

Article Multidisciplinary Sciences

Structures of pyruvate kinases display evolutionarily divergent allosteric strategies

Hugh P. Morgan et al.

ROYAL SOCIETY OPEN SCIENCE (2014)

Article Biochemical Research Methods

'In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase

Wenhe Zhong et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2013)

Article Biochemical Research Methods

Handling Uncertainty in Dynamic Models: The Pentose Phosphate Pathway in Trypanosoma brucei

Eduard J. Kerkhoven et al.

PLOS COMPUTATIONAL BIOLOGY (2013)

Article Mathematical & Computational Biology

Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease

Arvind K. Chavali et al.

BMC SYSTEMS BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Multiple roles of proline transport and metabolism in trypanosomatids

Frederic Bringaud et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2012)

Article Parasitology

Extra-glycosomal localisation of Trypanosoma brucei hexokinase 2

April C. Joice et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY (2012)

Article Parasitology

Proliferating bloodstream-form Trypanosoma brucei use a negligible part of consumed glucose for anabolic processes

Jurgen R. Haanstra et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY (2012)

Review Parasitology

When, how and why glycolysis became compartmentalised in the Kinetoplastea. A new look at an ancient organelle

Melisa Gualdron-Lopez et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY (2012)

Review Biochemistry & Molecular Biology

Metabolomic analysis of trypanosomatid protozoa

Darren J. Creek et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2012)

Article Multidisciplinary Sciences

Channel-Forming Activities in the Glycosomal Fraction from the Bloodstream Form of Trypanosoma brucei

Melisa Gualdron-Lopez et al.

PLOS ONE (2012)

Article Biochemical Research Methods

Dynamic Modelling under Uncertainty: The Case of Trypanosoma brucei Energy Metabolism

Fiona Achcar et al.

PLOS COMPUTATIONAL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Arginine kinase in Phytomonas, a trypanosomatid parasite of plants

Gaspar E. Canepa et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2011)

Review Biochemistry & Molecular Biology

Glucose metabolism in Trypanosoma cruzi

Dante A. Maugeri et al.

ESSAYS IN BIOCHEMISTRY: MOLECULAR PARASITOLOGY (2011)

Article Biochemistry & Molecular Biology

Glycerol 3-Phosphate Alters Trypanosoma brucei Hexokinase Activity in Response to Environmental Change

Heidi C. Dodson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Complex I (NADH:ubiquinone oxidoreductase) is active in but non-essential for procyclic Trypanosoma brucei

Zdenek Verner et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2011)

Article Biochemistry & Molecular Biology

A domino effect in drug action: from metabolic assault towards parasite differentiation

Jurgen R. Haanstra et al.

MOLECULAR MICROBIOLOGY (2011)

Review Cell Biology

Methylglyoxal metabolism in trypanosomes and leishmania

Susan Wyllie et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Genetic validation of aldolase and glyceraldehyde-3-phosphate dehydrogenase as drug targets in Trypanosoma brucei

Ana Judith Caceres et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2010)

Article Parasitology

The silicon trypanosome

Barbara M. Bakker et al.

PARASITOLOGY (2010)

Article Parasitology

Central carbon metabolism of Leishmania parasites

Eleanor C. Saunders et al.

PARASITOLOGY (2010)

Article Biochemistry & Molecular Biology

Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites

Artur T. Cordeiro et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2009)

Article Mathematical & Computational Biology

Proteomic and network analysis characterize stage-specific metabolism in Trypanosoma cruzi

Seth B. Roberts et al.

BMC SYSTEMS BIOLOGY (2009)

Article Parasitology

Trypanosoma brucei AMP-activated kinase subunit homologs influence surface molecule expression

Clarice S. Clemmens et al.

EXPERIMENTAL PARASITOLOGY (2009)

Article Biochemical Research Methods

The Phosphoproteome of Bloodstream Form Trypanosoma brucei, Causative Agent of African Sleeping Sickness

Isabelle R. E. Nett et al.

MOLECULAR & CELLULAR PROTEOMICS (2009)

Article Biochemistry & Molecular Biology

Glucose uptake in the mammalian stages of Trypanosoma cruzi

Ariel M. Silber et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2009)

Article Biochemistry & Molecular Biology

Retooling Leishmania metabolism:: from sand fly gut to human macrophage

Doron Rosenzweig et al.

FASEB JOURNAL (2008)

Article Biochemistry & Molecular Biology

Assembly of heterohexameric trypanosome hexokinases reveals that hexokinase 2 is a regulable enzyme

Jeremy W. Chambers et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei

Virginie Coustou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Differential expression of glycosomal and mitochondrial proteins in the two major life-cycle stages of Trypanosoma brucei

Didier Vertommen et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2008)

Article Biochemistry & Molecular Biology

Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major

Arvind K. Chavali et al.

MOLECULAR SYSTEMS BIOLOGY (2008)

Article Multidisciplinary Sciences

Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes

Jurgen R. Haanstra et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemical Research Methods

Post-translational modification of cellular proteins during Leishmania donovani differentiation

Doron Rosenzweig et al.

PROTEOMICS (2008)

Article Biochemistry & Molecular Biology

Molecular and biochemical characterization of novel glucokinases from Trypanosoma cruzi and Leishmania spp.

Ana Judith Caceres et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2007)

Article Multidisciplinary Sciences

Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy

Julius Lukes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

Phenotypic characterization of a glucose transporter null mutant in Leishmania mexicana

Dayana Rodriguez-Contreras et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2007)

Article Parasitology

Purification and characterization of hexokinase from Leishmania mexicana

Miguel A. Pabon et al.

PARASITOLOGY RESEARCH (2007)

Article Biochemistry & Molecular Biology

Metabolic changes in glucose transporter-deficient Leishmania mexicana and parasite virulence

Dayana Rodriguez-Contreras et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Multidisciplinary Sciences

Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase

T Naderer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Experimental and in silico analyses of glycolytic flux control in bloodstream form Trypanosoma brucei

MA Albert et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

The Trypanosoma cruzi proteome

JA Atwood et al.

SCIENCE (2005)

Article Biochemistry & Molecular Biology

Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose

N Lamour et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Succinate secreted by Trypanosoma brucei is produced by a novel and unique glycosomal enzyme, NADH-dependent fumarate reductase

S Besteiro et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Mitochondrial substrate level phosphorylation is essential for growth of procyclic Trypanosoma brucei

N Bochud-Allemann et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Parasitology

Enzymes of carbohydrate metabolism as potential drug targets

FR Opperdoes et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY (2001)

Review Parasitology

Metabolic aspects of glycosomes in trypanosomatidae - New data and views

PAM Michels et al.

PARASITOLOGY TODAY (2000)

Article Biochemistry & Molecular Biology

Glycerol kinase of Trypanosoma brucei -: Cloning, molecular characterization and mutagenesis

I Králová et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)

Article Multidisciplinary Sciences

Compartmentation protects trypanosomes from the dangerous design of glycolysis

BM Bakker et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)