Hippocampal regenerative medicine: neurogenic implications for addiction and mental disorders

Mental health: Treatment hopes in the hippocampus A region of the brain called the hippocampus and its connections to other parts of the brain via what are called cortico-limbic structures are implicated in a variety of mental health disorders. These disorders can be accompanied by reduced hippocampal volume. Mi-Hyeon Jang, Doo-Sup Choi and colleagues at the Mayo Clinic College of Medicine and Science, Rochester, USA, review the role of hippocampal and cortico-limbic neurobiology in memory and mood in mental disorders. They focus particular attention on the role of neurogenesis, the production and growth of new nerve cells and connections. Disrupted neurogenesis in the adult hippocampus is implicated in conditions including addiction, depression, schizophrenia and related psychotic disorders. Learning more about neural regeneration in the hippocampus could yield insights into mental health conditions and open new avenues toward developing drug-based treatments. Psychiatric illness is a prevalent and highly debilitating disorder, and more than 50% of the general population in both middle- and high-income countries experience at least one psychiatric disorder at some point in their lives. As we continue to learn how pervasive psychiatric episodes are in society, we must acknowledge that psychiatric disorders are not solely relegated to a small group of predisposed individuals but rather occur in significant portions of all societal groups. Several distinct brain regions have been implicated in neuropsychiatric disease. These brain regions include corticolimbic structures, which regulate executive function and decision making (e.g., the prefrontal cortex), as well as striatal subregions known to control motivated behavior under normal and stressful conditions. Importantly, the corticolimbic neural circuitry includes the hippocampus, a critical brain structure that sends projections to both the cortex and striatum to coordinate learning, memory, and mood. In this review, we will discuss past and recent discoveries of how neurobiological processes in the hippocampus and corticolimbic structures work in concert to control executive function, memory, and mood in the context of mental disorders.

Automated summary

Mental health disorders are linked to the neurobiology of the hippocampus and cortico-limbic structures, with disrupted neurogenesis contributing to conditions such as addiction, depression, and schizophrenia. Understanding neural regeneration in the hippocampus may offer new insights into treating mental health conditions.