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The Impact of Insulin Resistance on Cardiovascular Control During Exercise in Diabetes

Journal

EXERCISE AND SPORT SCIENCES REVIEWS
Volume 49, Issue 3, Pages 157-167

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000259

Keywords

insulin resistance; hyperglycemia; diabetes; exercise blood pressure; sympathetic nerve activity; exercise pressor reflex; central command

Funding

  1. National Institutes of Health [R01-HL-151632, R01-HL-133179, P30DK079328]

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Research suggests that high levels of insulin or blood glucose significantly impact neural regulatory pathways controlling circulation during exercise in diabetic patients.
Patients with diabetes display heightened blood pressure response to exercise, but the underlying mechanism remains to be elucidated. There is no direct evidence that insulin resistance (hyperinsulinemia or hyperglycemia) impacts neural cardiovascular control during exercise. We propose a novel paradigm in which hyperinsulinemia or hyperglycemia significantly influences neural regulatory pathways controlling the circulation during exercise in diabetes.

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