4.5 Article

Asymmetric Synthesis of N-Fmoc-(S)-7-aza-tryptophan via Alkylation of Chiral Nucleophilic Glycine Equivalent

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Asymmetric synthesis of (S)-3-methyleneglutamic acid and its N-Fmoc derivative via Michael addition-elimination reaction of chiral glycine Ni (II) complex with enol tosylates

Yuhei Shigeno et al.

Summary: The use of chiral Ni(II)-complexes of glycine Schiff bases has been proven as an effective method for asymmetric synthesis of Tailor-Made Amino Acids (TM), with promising results in the preparation of (S)-3-methyleneglutamic acid and its derivatives through a novel Michael addition-elimination reaction. The success of this approach presents a potential for broader applications in the field of biological studies.

CHIRALITY (2021)

Review Chemistry, Medicinal

Tailor-made amino acids in the design of small-molecule blockbuster drugs

Jianlin Han et al.

Summary: Amino acids play a significant role in the modern health industry, with individual amino acid residues or their chemical modifications commonly seen in modern pharmaceutical structures. Tailor-made amino acids are currently key structural features in many successful drugs, and this review profiles 14 small-molecule drugs to illustrate the diverse structural applications of amino acids in various therapeutic areas.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Chemistry, Medicinal

Applications of fluorine-containing amino acids for drug design

Haibo Mei et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Chemistry, Multidisciplinary

Tailor-Made Amino Acids and Fluorinated Motifs as Prominent Traits in Modern Pharmaceuticals

Haibo Mei et al.

CHEMISTRY-A EUROPEAN JOURNAL (2020)

Review Chemistry, Multidisciplinary

Fluorine-containing drugs approved by the FDA in 2019

Haibo Mei et al.

CHINESE CHEMICAL LETTERS (2020)

Review Biochemistry & Molecular Biology

Tailor-made amino acid-derived pharmaceuticals approved by the FDA in 2019

Zizhen Yin et al.

AMINO ACIDS (2020)

Review Chemistry, Medicinal

Cyclic tailor-made amino acids in the design of modern pharmaceuticals

Jiang Liu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Chemistry, Inorganic & Nuclear

Next generation organofluorine containing blockbuster drugs

Jianlin Han et al.

JOURNAL OF FLUORINE CHEMISTRY (2020)

Review Chemistry, Multidisciplinary

Fluorine-Containing Drugs Approved by the FDA in 2018

Haibo Mei et al.

CHEMISTRY-A EUROPEAN JOURNAL (2019)

Article Multidisciplinary Sciences

Convenient Asymmetric Synthesis of Fmoc-(S)-6,6,6-Trifluoro-Norleucine

Haibo Mei et al.

SYMMETRY-BASEL (2019)

Article Chemistry, Multidisciplinary

Large-Scale Asymmetric Synthesis of Fmoc-(S)-2-Amino-6,6,6-Trifluorohexanoic Acid

Zizhen Yin et al.

CHEMISTRYOPEN (2019)

Article Chemistry, Organic

Development of a peptide-based fluorescent probe for biological heme monitoring

Laura D. Newton et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2019)

Article Chemistry, Multidisciplinary

De novo Biosynthesis of Non-Natural Thaxtomin Phytotoxins

Michael Winn et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Review Biochemistry & Molecular Biology

Recent approaches for asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes

Yibing Wang et al.

AMINO ACIDS (2017)

Article Chemistry, Medicinal

Unusual Amino Acids in Medicinal Chemistry

Mark A. T. Blaskovich

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Chemistry, Multidisciplinary

Recyclable Ligands for the Non-Enzymatic Dynamic Kinetic Resolution of Challenging -Amino Acids

Yong Nian et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Article Chemistry, Multidisciplinary

Chemical Kinetic Resolution of Unprotected β-Substituted β-Amino Acids Using Recyclable Chiral Ligands

Shengbin Zhou et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Article Chemistry, Multidisciplinary

Chemical Dynamic Kinetic Resolution and S/R Interconversion of Unprotected α-Amino Acids

Ryosuke Takeda et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Article Chemistry, Medicinal

Amino acidic scaffolds bearing unnatural side chains: An old idea generates new and versatile tools for the life sciences

Andrea Stevenazzi et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

Article Chemistry, Medicinal

Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1

Lewis Gazzard et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

Article Chemistry, Multidisciplinary

Efficient asymmetric synthesis of trifluoromethylated β-aminophosphonates and their incorporation into dipeptides

Kostiantyn V. Turcheniuk et al.

CHEMICAL COMMUNICATIONS (2012)

Review Chemistry, Multidisciplinary

Drug Discovery Targeting Amino Acid Racemases

Paola Conti et al.

CHEMICAL REVIEWS (2011)

Article Chemistry, Medicinal

Drug to Genome to Drug: Discovery of New Antiplasmodial Compounds

Terence B. Beghyn et al.

JOURNAL OF MEDICINAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Azatryptophans as tools to study polarity requirements for folding of green fluorescent protein

Michael Georg Hoesl et al.

JOURNAL OF PEPTIDE SCIENCE (2010)

Review Chemistry, Organic

Practical Methods for the Synthesis of Symmetrically α,α-Disubstituted α-Amino Acids

Vadim A. Soloshonok et al.

SYNTHESIS-STUTTGART (2010)

Article Chemistry, Organic

Synthesis of C3-substituted 4-azaindoles: An easy access to 4-azamelatonin and protected 4-azatryptophan

Matthieu Jeanty et al.

JOURNAL OF ORGANIC CHEMISTRY (2008)

Article Chemistry, Organic

New practical access to 2-azatryptophans and dehydro derivatives via the Wittig-Horner reaction

Francois Crestey et al.

TETRAHEDRON LETTERS (2007)

Article Chemistry, Multidisciplinary

Design, synthesis, and characterization of binuclear Ni(II) complexes with inherent helical chirality

Vadim A. Soloshonok et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Chemistry, Organic

A new and efficient synthesis of 2-azatryptophans

Francois Crestey et al.

TETRAHEDRON (2006)

Article Biochemical Research Methods

Expression of compstatin in Escherichia coli:: Incorporation of unnatural amino acids enhances its activity

Madan Katragadda et al.

PROTEIN EXPRESSION AND PURIFICATION (2006)

Article Biochemistry & Molecular Biology

Efficient biosynthetic incorporation of tryptophan and indole analogs in an integral membrane protein

J Broos et al.

PROTEIN SCIENCE (2003)