Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2021, Issue 21, Pages 2962-2965Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202100485
Keywords
Aza-tryptophanes; Asymmetric synthesis; Chiral tridentate ligands; Ni catalysis; Tailor-Made Amino Acids (TM); Schiff bases
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Ni(II) complexes derived from glycine Schiff bases with chiral tridentate ligands have been used as powerful tools for synthesizing structurally diverse tailor-made amino acids. An asymmetric alkylation reaction between chiral nucleophilic glycine derived Ni-complex and 3-(chloromethyl)-1H-pyrrolo[2,3-b]pyridine has been developed under convenient conditions, yielding the alkylated Ni-complex in 74% yield with excellent diastereoselectivity. This reaction features convenient conditions and completely controlled diastereoselectivity, providing a valuable approach for asymmetric synthesis of 7-aza-tryptophan.
Ni(II)-complexes, derived from glycine Schiff bases with chiral tridentate ligands, have been used as powerful tools for the synthesis of structurally diverse tailor-made amino acids. In this manuscript, asymmetric alkylation reaction between chiral nucleophilic glycine derived Ni-complex and 3-(chloromethyl)-1H-pyrrolo[2,3-b]pyridine has been developed under convenient conditions, which affords the corresponding alkylated Ni-complex in 74 % yield and excellent diastereoselectivity (only one isomer). This reaction features convenient conditions and completely controlled diastereoselectivity, which provides a highly valuable approach for asymmetric synthesis of 7-aza-tryptophan.
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