Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2021, Issue 20, Pages 2887-2900Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202100244
Keywords
Carbocycles; Heterocycles; Non-natural amino acids; Peptidomimetics; Turn secondary structure mimics
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This review emphasizes the recent advances in the design and synthesis of cyclic turn mimics, focusing on their ability to induce gamma-, beta-, and alpha-turns in peptidomimetics.
The main goal in developing peptidomimetics is the stabilization of the bioactive conformation of peptides. Among all the secondary structures, turns are of paramount importance. This review highlights the recent advances in the design and synthesis of cyclic turn mimics. Both amino acids, carbo- and hetero-cyclic scaffolds have been considered, focusing on their use in the preparation of peptidomimetics and on their ability to induce gamma-, beta-, and alpha-turns.
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