Electrochemical Tandem Cyclization of Unsaturated Oximes with Diselenides: A General Approach to Seleno Isoxazolines Derivatives with Quaternary Carbon Center

Electrochemical oxidative tandem cyclization of unsaturated oximes with diselenides has been developed to provide a general access to seleno isoxazolines containing a quaternary carbon center (35 examples). This novel protocol features with mild reaction conditions (metal- and oxidant-free), good functional group tolerance and promising scalability. Moreover, plausible reaction pathways have been proposed.

Automated summary

An electrochemical oxidative tandem cyclization of unsaturated oximes with diselenides has been developed, providing a general access to seleno isoxazolines containing a quaternary carbon center (35 examples). This novel protocol features mild reaction conditions (metal- and oxidant-free), good functional group tolerance, and promising scalability, with plausible reaction pathways proposed.