Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2021, Issue 14, Pages 2103-2106Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202100148
Keywords
Alcohols; Boron; Chemoselectivity; Deoxygenation; Silanes
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The chemoselective deoxygenation of secondary benzylic alcohols can be achieved through a series of formylation and reduction reactions, forming formates. In this process, the formyl group acts as both an activator and a self-sacrificing protecting group, allowing the reaction to proceed in the presence of other reducible groups.
A sequence of formylation and B(C6F5)(3)-catalyzed reduction of the resulting formate with Et3SiH enables the chemoselective deoxygenation of secondary benzylic alcohols. Primary benzylic and tertiary non-benzylic alcohols are not reduced by this protocol. The formyl group fulfills a double role as activator and self-sacrificing protecting group. The deoxygenation of these formates is fast and can be carried out in the presence of other potentially reducible groups. Neighboring-group participation was found in the deoxygenation of certain diol motifs.
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