About the source and consequences of 18F-FDG brain PET hypometabolism in short and long COVID-19

Article Cell & Tissue Engineering

ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response

Cheng Wang et al.

Summary: The study suggests a potential causal role of ApoE4 in the severity of COVID-19, as tested in human-induced pluripotent stem cell (hiPSC) models for SARS-CoV-2 neurotropism. Increased infection rates of SARS-CoV-2 in ApoE4/4 neurons and astrocytes were observed, with changes in ApoE4 astrocytes upon infection. Remdesivir treatment was effective in inhibiting SARS-CoV2 infection in hiPSC neurons and astrocytes, highlighting the impact of risk factors on COVID-19 severity.

CELL STEM CELL (2021)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study

Aurelie Kas et al.

Summary: This study examined the longitudinal brain metabolic pattern in COVID-19-related encephalopathy using 18F-FDG-PET/CT. It found a consistent pattern of hypometabolism in various brain regions, with patients presenting with cognitive and behavioral disorders in the acute phase and ongoing cognitive and emotional symptoms 6 months after disease onset.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

18F-FDG brain PET hypometabolism in patients with long COVID

E. Guedj et al.

Summary: In long COVID patients, brain PET scans showed significant hypometabolism in areas including bilateral rectal/orbital gyrus, temporal lobe, brainstem, and cerebellum. These metabolic abnormalities were associated with more functional complaints such as hyposmia/anosmia, memory/cognitive impairment, pain, and insomnia. The study suggests a potential biomarker value in identifying and monitoring long COVID patients, with implications for the impact of ACE drugs and nasal decongestant spray on brain metabolism.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

Add to Collection

Letter Radiology, Nuclear Medicine & Medical Imaging