Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume 54, Issue 1, Pages 4133-4140Publisher
WILEY
DOI: 10.1111/ejn.15250
Keywords
calcium channels; NMDA receptors; synapse
Categories
Funding
- Lewy Body Society [OOG 2019/2020]
- Qingdao University
- National Natural Science Foundation of China [32070772]
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This study reveals how neuronal activity rapidly regulates the recruitment of R-type VGCCs in hippocampal neurons through synaptic NMDAR signaling, suggesting a feedback mechanism for regulating synaptic Ca2+ signaling.
Regulation of extracellular Ca2+ influx by neuronal activity is a key mechanism underlying synaptic plasticity. At the neuronal synapse, activity-dependent Ca2+ entry involves N-methyl-D-aspartate receptors (NMDARs) and voltage-gated calcium channels (VGCCs); the relationship between NMDARs and VGCCs, however, is poorly understood. Here, we report that neuronal activity rapidly (1h) regulates recruitment of R-type VGCCs in hippocampal neurons through synaptic NMDAR signalling. This finding reveals a link between two key neuronal signalling pathways, suggesting a feedback mode for regulation of synaptic Ca2+ signalling.
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