Journal
EPILEPSY & BEHAVIOR
Volume 117, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2021.107799
Keywords
Corpus callosotomy; Developmental outcome; Seizure outcome; Infants and young children; Drug-resistant epilepsy
Categories
Funding
- Health and Labour Sciences Research Grants on rare and intractable diseases from the Ministry of Health, Labour and Welfare, Japan [H26-nanchitou-ippan-051, H29-nanchitou-ippan-010]
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This study aimed to investigate the developmental and seizure outcomes after corpus callosotomy in early childhood, finding that 42.5% of patients showed improved development postoperatively. Factors such as low preoperative developmental quotient, developmental gain one month after surgery, and postoperative seizure-free state were related to the improvement in postoperative developmental quotient.
Aim: To examine the developmental and seizure outcomes after corpus callosotomy (CC) in early childhood. Methods: We retrospectively identified 106 patients who underwent CC for drug-resistant epilepsy before the age of 6 years, at the Nagasaki Medical Center, between July 2002 and July 2016. Patients' developmental outcomes were evaluated one year after CC using the Kinder Infant Development Scale. Results: The mean preoperative developmental quotient (DQ) was 25.0 (standard deviation [SD], 20.8), and the mean difference between preoperative DQ and one-year postoperative DQ was -1.6 points (SD, 11.6). However, 42.5% of patients had a mean DQ increase of 6.5 points (SD, 6.4), one year after CC from that before surgery. Factors related to the improvement in postoperative DQ were 'low preoperative DQ', 'developmental gain 1 month postoperatively', and 'postoperative seizure-free state'. Approximately 21.7% of patients were seizure-free 1 year after CC. Interpretation: Performing CC, in infancy and early childhood for patients with drug-resistant epilepsy and severe developmental impairment, was associated with improved development in 42.5% of patients. Remission of seizures, even if only for a short period, contributed to developmental improvement. From a developmental perspective, CC for drug-resistant epilepsy in early childhood is an effective treatment. (C) 2021 Elsevier Inc. All rights reserved.
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