Journal
ENVIRONMENTAL SCIENCE & TECHNOLOGY
Volume 55, Issue 11, Pages 7551-7560Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.est.1c00931
Keywords
atenolol; carbamazepine; naproxen; correction factor; prescription data
Categories
Funding
- Queensland Alliance for Environmental Health Sciences
- Queensland Department of Health
Ask authors/readers for more resources
The study aimed to review and estimate the correction factors (CFs) for atenolol, carbamazepine, and naproxen in wastewater-based epidemiology (WBE) using data from Australia. The estimated CFs for atenolol and carbamazepine were found to be 1.37 and 8.69, respectively. Due to over-the-counter sales of naproxen, a reliable CF could not be estimated based on prescription statistics.
The correction factor (CF) is a critical parameter in wastewater-based epidemiology (WBE) that significantly influences the accuracy of the final consumption estimates. However, most CFs have been derived from a few old pharmacokinetic studies and should be re-evaluated and refined to improve the accuracy of the WBE approach. This study aimed to review and estimate the CFs for atenolol, carbamazepine, and naproxen for WBE using the daily mass loads of those pharmaceuticals in wastewater and their corresponding dispensed prescription data in Australia. Influent wastewater samples were collected from wastewater treatment plants serving approximately 24% of the Australian population and annual national dispensed prescription data. The estimated CFs for atenolol and carbamazepine are 1.37 (95% CI: 1.17-1.66) and 8.69 (95% CI: 7.66-10.03), respectively. Due to significant over-the-counter sales of naproxen, a reliable CF could not be estimated based on prescription statistics. Using an independent dataset of 186 and 149 wastewater samples collected in an urban catchment in 2011 and 2012, WBE results calculated using the new CFs matched well with the dispensed data for atenolol and carbamazepine in the catchment area.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available