How Much of the Total Organic Halogen and Developmental Toxicity of Chlorinated Drinking Water Might Be Attributed to Aromatic Halogenated DBPs?

Although >700 disinfection byproducts (DBPs) have been identified, >50% of the total organic halogen (TOX) in drinking water chlorination is unknown, and the DBPs responsible for the chlorination-associated health risks remain largely unclear. Recent studies have revealed numerous aromatic halo-DBPs, which generally present substantially higher developmental toxicity than aliphatic halo-DBPs. This raises a fascinating and important question: how much of the TOX and developmental toxicity of chlorinated drinking water can be attributed to aromatic halo-DBPs? In this study, an effective approach with ultraperformance liquid chromatography was developed to separate the DBP mixture (from chlorination of bromide-rich raw water) into aliphatic and aromatic fractions, which were then characterized for their TOX and developmental toxicity. For chlorine contact times of 0.25-72 h, aromatic fractions accounted for 49-67% of the TOX in the obtained aliphatic and aromatic fractions, which were equivalent to 26-36% of the TOX in the original chlorinated water samples. Aromatic halo-DBP fractions were more developmentally toxic than the corresponding aliphatic fractions, and the overall developmental toxicity of chlorinated water samples was dominated by aromatic halo-DBP fractions. This might be explained by the considerably higher potentials of aromatic halo-DBPs to bioconcentrate and then generate reactive oxygen species in the organism.

Automated summary

The study developed an effective method with ultraperformance liquid chromatography to analyze the DBP mixture from chlorination of bromide-rich raw water, separating them into aliphatic and aromatic fractions. The results showed that aromatic fractions accounted for a significant portion of the TOX and developmental toxicity in the original chlorinated water samples, indicating that the overall developmental toxicity of chlorinated water is mainly attributed to aromatic halo-DBPs with high bioconcentration potential.