Journal
ELECTROCHIMICA ACTA
Volume 379, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.electacta.2021.138174
Keywords
Norfloxacin; AuNPs; CoFe-MOFs; Polypyrrole; Molecular imprinted polymer; Electrochemical trace detection
Categories
Funding
- National Natural Science Foundation of China [31360387]
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A method for electrochemical trace detection of NOR was developed using Ppy-based MIP-coated 3D CoFe-MOFs with AuNPs. After modification, CoFe-MOFs/AuNPs generated more imprinted cavities, contributing to a lower detection limit of 0.131 pmol L-1 and a wider linear range. Rapid and precise detection of NOR was achieved in prescription and pure milk, showing high potential for trace detection in environmental and animal foods.
Coated with polypyrrole (Ppy)-based molecularly imprinted polymer (MIP), 3D CoFe-metal organic frameworks (CoFe-MOFs) with gold nanoparticles (AuNPs) was developed for electrochemical trace detection of norfloxacin (NOR). On one hand, the trace detection of NOR was realized with MIP/CoFeMOFs/AuNPs/Glassy carbon electrode (GCE). The effective surface area of the imprinted cavities capable of identifying NOR on MIP/CoFe-MOFs/AuNPs/GCE increased to 0.1058 cm(2) after 3D CoFe-MOFs/AuNPs was modified, which indicates that CoFe-MOFs/AuNPs could generate more imprinted cavities, thus contributing to a lower limit of detection (LOD) of 0.131 pmol L-1 (S/N = 3) with a wider linear range (5-100, 100-1000 and 1000-6000 pmol L-1). On the other hand, the recognition reaction to NOR by MIP/CoFe-MOFs/AuNPs/GCE is an irreversible electrochemical oxidation reaction involving an electron and a proton, controlled by a mixed adsorption-diffusion mechanism. Rapid and precise detection of NOR in prescription (norfloxacin capsules with the specification of 0.1 g) and pure milk with the recovery rates between 97.04 and 110.2% and the relative standard deviations (RSD) were less than 5.7%. The measured results by MIP/CoFe-MOFs/AuNPs/GCE were close to the commercial norfloxacin enzyme-linked immunosorbent assay (ELISA) kit, demonstrates its high potential to NOR trace detection in environmental and animal foods. (C) 2021 Elsevier Ltd. All rights reserved.
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