Journal
BRAIN PATHOLOGY
Volume 25, Issue 3, Pages 350-364Publisher
WILEY
DOI: 10.1111/bpa.12248
Keywords
Alzheimer's disease; chronic traumatic encephalopathy; tauopathy; TDP-43; traumatic brain injury
Categories
Funding
- National Institute of Neurological Disorders and Stroke [1UO1NS086659-01]
- Department of Veterans Affairs, the Veterans Affairs Biorepository [CSP 501]
- Translational Research Center for Traumatic Brain Injury and Stress Disorders (TRACTS), Veterans Affairs Rehabilitation Research and Development Traumatic Brain Injury Center of Excellence [B6796-C]
- National Institute of Aging Boston University Alzheimer's Disease Center [P30AG13846, 0572063345-5]
- National Institute of Aging Boston University Framingham Heart Study [AG1649]
- National Operating Committee on Standards for Athletic Equipment
- Sports Legacy Institute
- Andlinger Foundation
- WWE
- National Football League
Ask authors/readers for more resources
Repetitive brain trauma is associated with a progressive neurological deterioration, now termed as chronic traumatic encephalopathy (CTE). Most instances of CTE occur in association with the play of sports, but CTE has also been reported in association with blast injuries and other neurotrauma. Symptoms of CTE include behavioral and mood changes, memory loss, cognitive impairment and dementia. Like many other neurodegenerative diseases, CTE is diagnosed with certainty only by neuropathological examination of brain tissue. CTE is a tauopathy characterized by the deposition of hyperphosphorylated tau (p-tau) protein as neurofibrillary tangles, astrocytic tangles and neurites in striking clusters around small blood vessels of the cortex, typically at the sulcal depths. Severely affected cases show p-tau pathology throughout the brain. Abnormalities in phosphorylated 43kDa TAR DNA-binding protein are found in most cases of CTE; beta-amyloid is identified in 43%, associated with age. Given the importance of sports participation and physical exercise to physical and psychological health as well as disease resilience, it is critical to identify the genetic risk factors for CTE as well as to understand how other variables, such as stress, age at exposure, gender, substance abuse and other exposures, contribute to the development of CTE.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available