Journal
DRUG DISCOVERY TODAY
Volume 26, Issue 10, Pages 2397-2405Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2021.04.012
Keywords
Cancer; Intratumoral administration; Stimuli-responsive hydrogels
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This article provides an overview of using hydrogels for drug delivery, highlighting the advantages of intratumoral administration by endowing hydrogels with responsiveness to different stimuli.
The ability of some hydrogels to exhibit a phase transition or change their structure in response to stimuli has been extensively explored for drug depot formation and controlled drug release. Taking advantage of the unique features of the tumor microenvironment (TME) or externally applied triggers, several injectable stimuli-responsive hydrogels have been described as promising candidates for intratumoral drug delivery. In this review, we provide a brief overview of the TME and highlight the advantages of intratumoral administration, followed by a summary of the reported strategies to endow hydrogels with responsiveness to physical (temperature and light), chemical (pH and redox potential), or biological (enzyme) stimuli.
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