Journal
DRUG DISCOVERY TODAY
Volume 26, Issue 7, Pages 1689-1701Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2021.03.004
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [81900482]
- Postdoctoral Research Program, Fudan University, Shanghai, China
Ask authors/readers for more resources
Solute carrier (SLC) transporters play diverse roles in tumor modulation, not only through influx/efflux mechanisms but also by activating signaling network cascades that drive metastatic tumor formation. However, further research is needed to fully understand the implications of these proteins in cancer pathogenesis.
Solute carrier (SLC) transporters are primarily known for their function in the transportation of various exogenous/endogenous substances via influx/efflux mechanisms. In addition to their diverse role in several tumor-modulating functions, such as proliferation, migration, angiogenesis, epithelial-mesenchymal transition (EMT), epigenetic modification, chemoresistance, immunoregulation, and oncometabolism, influx/efflux-independent contributions of SLCs in the activation of various signaling network cascades that might drive metastatic tumor formation have also been uncovered. Disappointingly, even after two decades and the discovery of >450 SLCs, many of their members remain orphans in terms of cancer pathogenesis. In this review, we summarize the current understanding of the tumor-modulating functions, mechanisms, and complexity of SLCs, as well as their potential as targets for cancer therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available