Targeting the endocannabinoid system in diabesity: Fact or fiction?

'Diabesity' refers to a rising epidemic indicated by the intricate relationship between obesity and diabetes. The global prevalence of these coexisting, insidious diseases increases social and economic health burdens at a rapid pace. Numerous reports delineate the involvement of the underlying endocannabinoid (EC) signaling system through the cannabinoid-1 (CB1) receptor in the regulation of metabolism and adiposity. Conversely, EC inverse agonists can result in severe depression and suicidal thoughts through interactions with CB1/2 receptors in the brain. This review attempts to elucidate a possible mechanism for the amelioration of diabesity. Moreover, we also highlight the available targets of the CB1 receptor, which could pave the way for safe and effective therapy.

Automated summary

The review discusses the intricate relationship between obesity and diabetes, highlighting the involvement of endocannabinoid signaling system and CB1 receptor in regulating metabolism and adiposity. However, excessive activation of the EC system may result in severe consequences, such as depression and suicidal thoughts.