4.7 Review

Cholesterol transport between cellular membranes: A balancing act between interconnected lipid fluxes

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms

Xu Xiao et al.

Summary: Aster proteins mediate nonvesicular plasma membrane to endoplasmic reticulum cholesterol transport, with 20 alpha-hydroxycholesterol and U18666A identified as potential small molecule modulators. However, they target other sterol homeostatic proteins, limiting their utility.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Biochemistry & Molecular Biology

Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b

Bilge Ercan et al.

Summary: The GRAM domain of GRAMD1b plays a crucial role in detecting cholesterol and anionic lipids, with mutations potentially leading to intellectual disabilities in humans. Cell utilize the GRAM domain to regulate the rate of cholesterol transport and membrane tethering.

EMBO JOURNAL (2021)

Review Cell Biology

Lipid Droplet Nucleation

Abdou Rachid Thiam et al.

Summary: This review focuses on the nucleation step of lipid droplet assembly, discussing how membrane biophysical and physicochemical properties control this process and the role of proteins in orchestrating lipid droplet biogenesis.

TRENDS IN CELL BIOLOGY (2021)

Article Cell Biology

The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi membrane contact sites

Yuichi Wakana et al.

Summary: The study reveals that in cholesterol-fed cells, SCAP interacts with the VAP-OSBP complex at ER-Golgi membrane contact sites to facilitate CARTS biogenesis. Knockdown of SCAP inhibits PI4P turnover and alters the subcellular distribution of the VAP-OSBP complex, ultimately leading to decreased CARTS formation.

JOURNAL OF CELL BIOLOGY (2021)

Review Cell Biology

The functional universe of membrane contact sites

William A. Prinz et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Cell Biology

Defining raft domains in the plasma membrane

Akihiro Kusumi et al.

TRAFFIC (2020)

Article Biochemistry & Molecular Biology

Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape

J. H. Lorent et al.

NATURE CHEMICAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Aster Proteins Regulate the Accessible Cholesterol Pool in the Plasma Membrane

Alessandra Ferrari et al.

MOLECULAR AND CELLULAR BIOLOGY (2020)

Article Multidisciplinary Sciences

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

Michael N. Trinh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

Dick J. H. van den Boomen et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts

Thomas Di Mattia et al.

EMBO JOURNAL (2020)

Article Biochemistry & Molecular Biology

Molecular Discrimination between Two Conformations of Sphingomyelin in Plasma Membranes

Shreya Endapally et al.

Article Biochemistry & Molecular Biology

The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis

Luca Laraia et al.

NATURE CHEMICAL BIOLOGY (2019)

Editorial Material Cell Biology

Shuttling HDL Cholesterol to the Membrane via Metastable Receptor Multimers

Elina Ikonen et al.

DEVELOPMENTAL CELL (2019)

Review Biochemistry & Molecular Biology

Rafts: A nickname for putative transient nanodomains

Felix M. Goni

CHEMISTRY AND PHYSICS OF LIPIDS (2019)

Review Cell Biology

Mechanisms of cellular cholesterol compartmentalization: recent insights

Elina Ikonen

CURRENT OPINION IN CELL BIOLOGY (2018)

Article Cell Biology

The Rab11-binding protein REL CH/KIAA1468 controls intracellular cholesterol distribution

Tomoaki Sobajima et al.

JOURNAL OF CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Endoplasmic reticulum-plasma membrane contact sites integrate sterol and phospholipid regulation

Evan Quon et al.

PLOS BIOLOGY (2018)

Article Multidisciplinary Sciences

Macrophages release plasma membrane-derived particles rich in accessible cholesterol

Cuiwen He et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

Sterol transfer, PI4P consumption, and control of membrane lipid order by endogenous OSBP

Bruno Mesmin et al.

EMBO JOURNAL (2017)

Article Biochemistry & Molecular Biology

STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites

Lea P. Wilhelm et al.

EMBO JOURNAL (2017)

Article Multidisciplinary Sciences

A phosphatidylinositol-4-phosphate powered exchange mechanism to create a lipid gradient between membranes

Joachim Moser von Filseck et al.

NATURE COMMUNICATIONS (2015)

Review Cell Biology

Phospholipid Synthesis and Transport in Mammalian Cells

Jean E. Vance

TRAFFIC (2015)

Article Biochemistry & Molecular Biology

Side-Chain Oxysterols Modulate Cholesterol Accessibility through Membrane Remodeling

Agata A. Bielska et al.

BIOCHEMISTRY (2014)

Review Cell Biology

Coordination between RAB GTPase and phosphoinositide regulation and functions

Steve Jean et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Cell Biology

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

Maud de Saint-Jean et al.

JOURNAL OF CELL BIOLOGY (2011)

Review Biochemistry & Molecular Biology

Intracellular sterol dynamics

Bruno Mesmin et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2009)

Article Biochemistry & Molecular Biology

Requirement of Myosin Vb.Rab11a.Rab11-FIP2 Complex in Cholesterol-regulated Translocation of NPC1L1 to the Cell Surface

Bei-Bei Chu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Review Cell Biology

Cellular cholesterol trafficking and compartmentalization

Elina Ikonen

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Article Cell Biology

Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells

Matts D. Linder et al.

MOLECULAR BIOLOGY OF THE CELL (2007)

Review Multidisciplinary Sciences

Phosphoinositides in cell regulation and membrane dynamics

Gilbert Di Paolo et al.

NATURE (2006)

Article Biochemistry & Molecular Biology

Sterol trafficking between the endoplasmic reticulum and plasma membrane in yeast

D. P. Sullivan et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2006)

Article Cell Biology

Modulation of cellular cholesterol transport and homeostasis by Rab11

M Hölttä-Vuori et al.

MOLECULAR BIOLOGY OF THE CELL (2002)

Article Multidisciplinary Sciences

Dissecting the role of the Golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface

S Heino et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)