Journal
DEVELOPMENTAL CELL
Volume 56, Issue 7, Pages 876-877Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2021.03.016
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TREX1 antagonizes DNA-mediated cGAS activation, playing a crucial role in preventing autoimmunity. New aspects of this important control mechanism are uncovered in studies by Mohr et al. (2021) and Zhou et al. (2021).
Coupling DNA sensing to the initiation of immune responses necessitates auxiliary control mechanisms to avoid autoimmunity. A key factor is the exonuclease TREX1, which antagonizes DNA-mediated activation of cGAS. Two studies, by Mohr et al. (2021) and Zhou et al. (2021), uncover new aspects of this important control mechanism.
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