Hedgehog signaling and the primary cilium: implications for spatial and temporal constraints on signaling

The mechanisms of vertebrate Hedgehog signaling are linked to the biology of the primary cilium, an antenna-like organelle that projects from the surface of most vertebrate cell types. Although the advantages of restricting signal transduction to cilia are often noted, the constraints imposed are less frequently considered, and yet they are central to how Hedgehog signaling operates in developing tissues. In this Review, we synthesize current understanding of Hedgehog signal transduction, ligand secretion and transport, and cilia dynamics to explore the temporal and spatial constraints imposed by the primary cilium on Hedgehog signaling in vivo.

Automated summary

Vertebrate Hedgehog signaling mechanisms are closely linked to the biology of the primary cilium, which imposes temporal and spatial constraints on the signaling pathway in developing tissues.