Journal
DERMATOLOGY
Volume 238, Issue 1, Pages 148-155Publisher
KARGER
DOI: 10.1159/000514687
Keywords
Chronic wounds; Clinical research; Epidemiology; Granulomatous disorder; Necrobiosis lipoidica; Skin diseases; Wound healing
Categories
Ask authors/readers for more resources
This study evaluated the therapeutic approaches and efficacy for 98 patients with NL. Common comorbidities included diabetes and thyroidal disorders. Topical steroids were predominantly used, while systemic application of fumaric acid esters and dapsone showed remarkable efficacy as alternatives to the use of steroids.
Background: Necrobiosis lipoidica (NL) is a rare granulomatous disorder of unknown aetiology. Randomized controlled studies are not available due to it being an orphan disease. Objectives: We evaluated patients in 2 dermatological centres to cluster data about epidemiology, the therapeutic approaches for NL, and their efficacy. Materials and Methods: Comorbidity and the efficacy of the applied treatment was assessed for 98 patients. Results: We identified 54% of patients with concomitant diabetes and 19% with thyroidal disorders. Topical steroids (85.7%) were predominantly used followed by calcineurin inhibitors (31%) and phototherapy (41.8%). Systemically, fumaric acid esters were more frequently applied (26.8%) than steroids (24.4%) and dapsone (24.4%). Steroids, compression therapy, calcineurin inhibitors, phototherapy, fumaric acid esters, and dapsone showed remarkable efficacy. Conclusion: Therapeutic options were chosen individually in accordance with the severity of NL and presence of ulceration. Topical calcineurin inhibitors, systemic application of fumaric acid esters, and dapsone represent effective alternatives to the use of steroids. (c) 2021 S. Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available