Post-traumatic Headache and Mild Traumatic Brain Injury: Brain Networks and Connectivity

Purpose of Review Post-traumatic headache (PTH) consequent to mild traumatic brain injury (mTBI) is a complex, multidimensional, chronic neurological disorder. The purpose of this review is to evaluate the current neuroimaging studies on mTBI and PTH with a specific focus on brain networks and connectivity patterns. Recent Findings We present findings on PTH incidence and prevalence, as well as the latest neuroimaging research findings on mTBI and PTH. Additionally, we propose a new strategy in studying PTH following mTBI. The diversity and heterogeneity of pathophysiological mechanisms underlying mild traumatic brain injury pose unique challenges on how we interpret neuroimaging findings in PTH. Evaluating alterations in the intrinsic brain network connectivity patterns using novel imaging and analytical techniques may provide additional insights into PTH disease state and therefore inform effective treatment strategies.

Automated summary

This review focuses on evaluating current neuroimaging studies on mTBI and PTH, with a specific focus on brain networks and connectivity patterns, and presents findings on PTH incidence and prevalence. The diverse pathophysiological mechanisms of mTBI pose unique challenges in interpreting neuroimaging findings in PTH.