The e-psychonaut drugs' psychopharmacology

The focus here was on the pharmacological and clinical pharmacological issues pertaining to the vast range of drugs (e.g. synthetic cannabimimetics, synthetic opioids, novel stimulants, novel psychedelics, PCP/ketamine-like compounds, prescribed medicinal compounds and popular psychotropic herbs/plants) discussed by Internet-based enthusiasts of new/novel psychoactive substances (NPS), 'e-psychonauts'. Currently ongoing related in silico studies, followed by further in vitro and in vivo/preclinical studies, will hopefully provide important findings in terms of which molecules within each given NPS class may present with higher levels of receptor affinities, and hence clinical potency. Understanding the pharmacological characteristics/potency of those novel recreational molecules will hopefully help in predicting related NPS diffusion, morbidity and possible lethality data.

Automated summary

The focus is on discussing the pharmacological and clinical pharmacological issues related to a wide range of drugs by Internet-based enthusiasts of new psychoactive substances. Ongoing studies aim to provide important findings on receptor affinities and clinical potency of these novel recreational molecules for predicting NPS diffusion, morbidity, and potential lethality.