Reactive oxygen species modulators in pulmonary medicine

Adapted to effectively capture oxygen from inhaled air and deliver it to all other parts of the body, the lungs constitute the organ with the largest surface area. This makes the lungs more susceptible to airborne pathogens and pollutants that mediate pathologies through generation of reactive oxygen species (ROS). One pathological consequence of excessive levels of ROS production is pulmonary diseases that account for a large number of mortality and morbidity in the world. Of the various mechanisms involved in pulmonary disease pathogenesis, mitochondrial dysfunction takes prominent importance. Herein, we briefly describe the significance of oxidative stress caused by ROS in pulmonary diseases and some possible therapeutic strategies.

Automated summary

The lungs, with the largest surface area in the body, are more susceptible to airborne pathogens and pollutants that mediate pathologies through ROS. Excessive ROS production leads to pulmonary diseases, where mitochondrial dysfunction plays a prominent role, and therapeutic strategies include reducing oxidative stress.