Journal
CURRENT OPINION IN HEMATOLOGY
Volume 28, Issue 4, Pages 277-283Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOH.0000000000000661
Keywords
lineage-specific alternative splicing; SRSF2; U2AF1; ZRSR2
Categories
Funding
- Lady Tata Memorial International Awards for Research in Leukaemia
- ASH Research Restart Award
- Edward P. Evans MDS Foundation
- [R01 HL128239]
- [R01 CA251138]
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Recent studies have emphasized the critical role of splicing regulation in hematopoiesis, including characterization of splicing components in normal hematopoiesis, investigation of transcriptional alterations on splicing, and identification of stage-specific alternative splicing events during hematopoietic development. This provides insights on hematopoietic regulation at a co-transcriptional level, and further high-throughput RNA sequencing and genomic screens are needed to advance our understanding of critical alternative splicing patterns in shaping hematopoiesis.
Purpose of review Splicing mutations are among the most recurrent genetic perturbations in hematological malignancies, highlighting an important impact of splicing regulation in hematopoietic development. However, compared to our understanding of splicing factor mutations in hematological malignancies, studies of splicing components and alternative splicing in normal hematopoiesis have been less well investigated. Here, we outline the most recent findings on splicing regulation in normal hematopoiesis and discuss the important questions in the field. Recent findings Recent studies have highlighted the critical role of splicing regulation in hematopoiesis, including characterization of splicing components in normal hematopoiesis, investigation of transcriptional alterations on splicing, and identification of stage-specific alternative splicing events during hematopoietic development. Summary These interesting findings provide insights on hematopoietic regulation at a co-transcriptional level. More high-throughput RNA ribonucleic acid (RNA) sequencing and functional genomic screens are needed to advance our knowledge of critical alternative splicing patterns in shaping hematopoiesis.
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