Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 67, Issue -, Pages 5-9Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2020.10.001
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Funding
- N.I.H. [GM118147]
- [N.I.H.R35GM133425]
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Recent studies have shown that active transcription foci contain clusters of transcriptional activators and Pol II, with implications on the regulation of gene activity.
There has been a sea change in our view of transcription regulation during the past decade (Fukaya et al., 2016, Lim et al., 2018, Hnisz et al., 2017 [3], Liu et al., 2018 [4], Kato et al., 2012). Classical models of enhancer-promoter interactions and the stepwise assembly of individual RNA Polymerase II (Pol II) complexes have given way to the realization that active transcription foci contain clustershubs-of transcriptional activators and Pol II. Here we summarize recent findings pointing to the occurrence of transcription hubs and the implications of such hubs on the regulation of gene activity.
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