Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 61, Issue -, Pages 135-142Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2020.12.004
Keywords
Metallodrugs; Mechanism of action; X-ray absorption spectroscopy; Xray fluorescence microscopy.
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X-ray absorption spectroscopy and X-ray fluorescence microscopy are nondestructive techniques that require minimal sample manipulation, often used to investigate the fate of metallodrugs in physiological samples. These methods are advantageous in studying metallodrug localization and speciation.
X-ray absorption spectroscopy and X-ray fluorescence microscopy are two synchrotron-based techniques frequently deployed either individually or in tandem to investigate the fates of metallodrugs and their biotransformation products in physiologically relevant sample material. These X-ray methods confer advantages over other analytical techniques in that they are nondestructive and require minimal chemical or physical manipulation of the sample before analysis, conserving both chemical and spatial information of the element(s) under investigation. In this review, we present selected examples of the use of X-ray absorption spectroscopy and X-ray fluorescence microscopy in studies of metallodrug speciation and localisation in vivo, in cell spheroids and in intact tissues and organs, and offer recent highlights in the advances of these techniques as they pertain to research on metallodrug action.
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