Natural Sirtuin Modulators in Drup Discovery: A Review (2010-2020)

There have been intense research interests in sirtuins since the establishment of their regulatory roles in a myriad of pathological processes. In the last two decades, many research efforts have been dedicated to the development of sirtuin modulators. Although synthetic sirtuin modulators are the focus, natural modulators remain an integral part to be further explored in this area as they are found to possess therapeutic potential in various diseases, including cancers, neurodegenerative diseases, and metabolic disorders. Owing to the importance of this cluster of compounds, this review gives a current stand on the naturally occurring sirtuin modulators, associated molecular mechanisms, and their therapeutic benefits. Furthermore, comprehensive data mining resulted in detailed statistical data analysis pertaining to the developmental trend of sirtuin modulators from 2010-2020. Lastly, the challenges and future prospects of natural sirtuin modulators in drug discovery will also be discussed.

Automated summary

Since the discovery of the regulatory roles of sirtuins in various pathological processes, there has been a growing interest in researching sirtuins, particularly in the development of modulators. Natural modulators have therapeutic potential in treating various diseases, and this review provides insights into their molecular mechanisms, therapeutic benefits, as well as the challenges and future prospects in drug discovery.