Liver Pseudolymphoma (Reactive Lymphoid Hyperplasia): Difficulty in Radiological and Pathological Diagnosis

Background: Pseudolymphoma of the liver (Reactive Lymphoid Hyperplasia) (RLH) is a rare condition. It is usually asymptomatic and detected incidentally on radiological imaging. Imaging features are similar to hepatic adenoma, hepatocellular carcinoma, cholangiocarcinoma, and malignant lymphoma and are not specific for pseudolymphoma of the liver. Percutaneous core biopsy is insufficient to distinguish pseudolymphoma of the liver from low-grade malignant lymphoma and extranodal marginal lymphomas. Case Descriptions: In this article, we present a case of hepatic RLH of a patient who was presented with a skin rash on the leg and was detected incidentally on radiological imaging. Conclusion: Preoperative definitive diagnosis of hepatic RLH using various imaging methods, including MRI with hepatocellular agents, is highly difficult.

Automated summary

Hepatic pseudolymphoma is a rare condition that is usually asymptomatic and often detected incidentally. Imaging features resemble other hepatic nodular lesions, making accurate diagnosis challenging. Differentiating it from other malignant lymphomas is also difficult with biopsy.