4.7 Article

Hydroxyapatite Nanoparticle Mesogens: Morphogenesis of pH-Sensitive Macromolecular Liquid Crystals

Journal

CRYSTAL GROWTH & DESIGN
Volume 21, Issue 4, Pages 2154-2166

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.cgd.0c01582

Keywords

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Funding

  1. Universidad Nacional del Sur (UNS) [PGI 24/Q092]
  2. Concejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) [PIP11220130100100CO]
  3. Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT) [PICT 201-0126]
  4. Comision de Investigaciones Cientificas (CIC), Argentina
  5. Xunta de Galicia (AEMAT) [ED431E2018/08, ED431B2017/21]
  6. CIC

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This study evaluates the chemical grafting of phosphorous amide and alpha-amino phosphonate molecular fragments on previously created biomimetic hydroxyapatite nanoparticles, providing a new application for the liquid crystal properties of biological molecular networks. The results demonstrate that under specific synthetic conditions, it is possible to obtain nanoparticles that act as mesogenic agents and self-assemble under pH stimulation.
Numerous living structural materials display self-assembly of building blocks. Biological molecular networks exhibit lyotropic liquid crystalline properties that can support non-equilibrium pathways influenced by dynamic processes at the microscale. With the aim of taking a further step toward the conquest of a biomimetic material to apply in calcified tissue regeneration, in this work, we have evaluated the chemical grafting of phosphorous amide (C-N-P) and alpha-amino phosphonate (N-C-P) molecular fragments on previously created biomimetic hydroxyapatite (HA) nanoparticles (nano-HA). Molecular combinations were selected due to their recognized capability of influencing bone physiology and pathology. We have assessed the effect of the type and degree of nano-HA substitution over the spontaneous self-association of acidic macromolecules that respond to pH stimulation. The produced materials were inspected by Fourier transform infrared and solid-state nuclear magnetic resonance spectroscopy, small-angle X-ray scattering, powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and polarized light and high-resolution electron transmission microscopy. A complete analysis of the experimental data proved that under specific synthetic conditions, it is possible to obtain substituted-HA nanoparticles that are able to act as mesogenic agents. These systems that dynamically respond to pH can be tailored in vitro to induce, at concentration values analogous to biogenic ones, lyotropic liquid crystal organization on acid macromolecules.

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